Drug interactions
Cenobamate + Warfarin
Severity: Moderate
Cenobamate and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces certain CYP enzymes and may lower warfarin exposure, reducing INR and anticoagulant effect. Cenobamate may also inhibit CYP2C19 and CYP2C9 effects, so the net effect can vary.
What this interaction means in plain words
Cenobamate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Cenobamate induces CYP3A4 and other enzymes, increasing warfarin metabolism.
What to do
Monitor INR more frequently when cenobamate is started, titrated or stopped and adjust the warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Warfarin?
MediHelp rates the interaction as moderate. Cenobamate and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces certain CYP enzymes and may lower warfarin exposure, reducing INR and anticoagulant effect. Cenobamate may also inhibit CYP2C19 and CYP2C9 effects, so the net effect can vary.
How serious is the interaction between Cenobamate and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when cenobamate is started, titrated or stopped and adjust the warfarin dose accordingly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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