Drug interactions
Cephalexin + Dapagliflozin-metformin
Severity: Moderate
Cephalexin and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin is eliminated by renal tubular secretion and may compete with metformin for transporters, raising metformin exposure. Raised levels increase lactic acidosis risk, particularly in patients with renal impairment.
What this interaction means in plain words
Cephalexin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of MATE1 and related renal transporters reduces metformin tubular secretion.
What to do
Monitor renal function and for signs of metformin excess; consider a metformin dose reduction in renal impairment or during prolonged cephalexin use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Cephalexin with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Cephalexin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin is eliminated by renal tubular secretion and may compete with metformin for transporters, raising metformin exposure. Raised levels increase lactic acidosis risk, particularly in patients with renal impairment.
How serious is the interaction between Cephalexin and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin excess; consider a metformin dose reduction in renal impairment or during prolonged cephalexin use.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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