Drug interactions
Cephalexin + Diflunisal
Severity: Minor
Cephalexin and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin and diflunisal are both organic acids eliminated partly by renal tubular secretion. Competition for this pathway could modestly raise diflunisal exposure, but a clinically meaningful effect has not been established.
What this interaction means in plain words
Cephalexin and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion may slightly reduce diflunisal clearance.
What to do
No routine change is needed; watch for NSAID adverse effects such as GI upset or reduced renal function if both are used in high doses or in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Cephalexin with Diflunisal?
MediHelp rates the interaction as minor. Cephalexin and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin and diflunisal are both organic acids eliminated partly by renal tubular secretion. Competition for this pathway could modestly raise diflunisal exposure, but a clinically meaningful effect has not been established.
How serious is the interaction between Cephalexin and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for NSAID adverse effects such as GI upset or reduced renal function if both are used in high doses or in renal impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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