Drug interactions
Cephalexin + Etodolac
Severity: Minor
Cephalexin and Etodolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin is secreted by renal tubular organic anion pathways and could compete with etodolac, theoretically raising its levels slightly. The effect is generally not clinically important.
What this interaction means in plain words
Cephalexin and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
No routine adjustment is needed. Monitor for NSAID adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Cephalexin with Etodolac?
MediHelp rates the interaction as minor. Cephalexin and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin is secreted by renal tubular organic anion pathways and could compete with etodolac, theoretically raising its levels slightly. The effect is generally not clinically important.
How serious is the interaction between Cephalexin and Etodolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for NSAID adverse effects in patients with renal impairment.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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