Drug interactions
Cephalexin + Indomethacin
Severity: Minor
Cephalexin and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin and indomethacin are both secreted by renal tubular anion transport, so indomethacin exposure could rise slightly. Clinically meaningful effects are not well established.
What this interaction means in plain words
Cephalexin and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anionic secretion.
What to do
No routine change needed. Monitor for indomethacin adverse effects and renal function if the patient has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Cephalexin with Indomethacin?
MediHelp rates the interaction as minor. Cephalexin and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin and indomethacin are both secreted by renal tubular anion transport, so indomethacin exposure could rise slightly. Clinically meaningful effects are not well established.
How serious is the interaction between Cephalexin and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Monitor for indomethacin adverse effects and renal function if the patient has renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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