Drug interactions
Cephalexin + Linagliptin-metformin
Severity: Moderate
Cephalexin and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin may compete with metformin for renal tubular secretion via OCT2 and MATE transporters, raising metformin concentrations. This could increase the risk of metformin accumulation and lactic acidosis in patients with impaired renal function.
What this interaction means in plain words
Cephalexin and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal tubular transport (MATE1/OCT2) reduces metformin clearance.
What to do
Monitor renal function and for signs of metformin toxicity, and consider reducing the metformin dose in patients with renal impairment during cephalexin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Cephalexin with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Cephalexin and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin may compete with metformin for renal tubular secretion via OCT2 and MATE transporters, raising metformin concentrations. This could increase the risk of metformin accumulation and lactic acidosis in patients with impaired renal function.
How serious is the interaction between Cephalexin and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity, and consider reducing the metformin dose in patients with renal impairment during cephalexin therapy.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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