Drug interactions
Cephalexin + Saxagliptin-metformin
Severity: Moderate
Cephalexin and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin can raise metformin concentrations by competing for renal tubular secretion. This may increase the risk of metformin accumulation and lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Cephalexin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of MATE-mediated renal tubular secretion of metformin.
What to do
Monitor glycemic response and renal function during cephalexin therapy, and consider reducing the metformin dose in patients with reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Cephalexin with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Cephalexin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin can raise metformin concentrations by competing for renal tubular secretion. This may increase the risk of metformin accumulation and lactic acidosis, especially in renal impairment.
How serious is the interaction between Cephalexin and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and renal function during cephalexin therapy, and consider reducing the metformin dose in patients with reduced eGFR.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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