Drug interactions
Certolizumab pegol + Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine
Severity: Minor
Certolizumab pegol and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination vaccine is non-live and can be given, but TNF blockade may reduce the antibody response to its components.
What this interaction means in plain words
Certolizumab pegol and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: immunosuppression may reduce vaccine immunogenicity.
What to do
Give indicated doses on schedule, preferably before starting certolizumab when practical. Do not delay vaccination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine?
MediHelp rates the interaction as minor. Certolizumab pegol and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The combination vaccine is non-live and can be given, but TNF blockade may reduce the antibody response to its components.
How serious is the interaction between Certolizumab pegol and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give indicated doses on schedule, preferably before starting certolizumab when practical. Do not delay vaccination.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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