Drug interactions
Certolizumab pegol + Hepatitis A vaccine inactivated
Severity: Minor
Certolizumab pegol and Hepatitis A vaccine inactivated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitors can blunt antibody responses to some vaccines. Inactivated hepatitis A vaccine is safe to give, but protection may be lower in patients on certolizumab.
What this interaction means in plain words
Certolizumab pegol and Hepatitis A vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Certolizumab pegol belongs to Musculoskeletal; Hepatitis A vaccine inactivated belongs to Anti Virals.
Why it happens
Immunosuppression from TNF blockade may reduce vaccine-induced antibody production.
What to do
Give the vaccine, ideally before starting certolizumab. Consider checking antibody titres afterwards in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Certolizumab pegol with Hepatitis A vaccine inactivated?
MediHelp rates the interaction as minor. Certolizumab pegol and Hepatitis A vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. TNF inhibitors can blunt antibody responses to some vaccines. Inactivated hepatitis A vaccine is safe to give, but protection may be lower in patients on certolizumab.
How serious is the interaction between Certolizumab pegol and Hepatitis A vaccine inactivated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine, ideally before starting certolizumab. Consider checking antibody titres afterwards in high-risk patients.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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