Drug interactions
Certolizumab pegol + Human papillomavirus vaccine quadrivalent
Severity: Minor
Certolizumab pegol and Human papillomavirus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitors can blunt antibody responses to some vaccines, so the HPV vaccine may produce a weaker immune response in patients on certolizumab pegol. The vaccine is not live and is not unsafe, but protection may be reduced. The clinical significance for HPV is uncertain, and the vaccine is generally still recommended.
What this interaction means in plain words
Certolizumab pegol and Human papillomavirus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression from TNF blockade may reduce vaccine-induced antibody responses.
What to do
Vaccinate when indicated, ideally before starting certolizumab pegol, and do not delay needed therapy. Complete the full vaccine series.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Human papillomavirus vaccine quadrivalent?
MediHelp rates the interaction as minor. Certolizumab pegol and Human papillomavirus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. TNF inhibitors can blunt antibody responses to some vaccines, so the HPV vaccine may produce a weaker immune response in patients on certolizumab pegol. The vaccine is not live and is not unsafe, but protection may be reduced. The clinical significance for HPV is uncertain, and the vaccine is generally still recommended.
How serious is the interaction between Certolizumab pegol and Human papillomavirus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated, ideally before starting certolizumab pegol, and do not delay needed therapy. Complete the full vaccine series.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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