Drug interactions
Certolizumab pegol + Influenza a vaccine
Severity: Minor
Certolizumab pegol and Influenza a vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The inactivated H5N1 vaccine may produce a weaker immune response in patients treated with a TNF inhibitor, though it is safe to give.
What this interaction means in plain words
Certolizumab pegol and Influenza a vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate when indicated and do not withhold certolizumab. Consider that protection may be reduced and use other preventive measures if exposed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza a vaccine?
MediHelp rates the interaction as minor. Certolizumab pegol and Influenza a vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The inactivated H5N1 vaccine may produce a weaker immune response in patients treated with a TNF inhibitor, though it is safe to give.
How serious is the interaction between Certolizumab pegol and Influenza a vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated and do not withhold certolizumab. Consider that protection may be reduced and use other preventive measures if exposed.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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