Drug interactions
Certolizumab pegol + Influenza virus vaccine quadrivalent recombinant
Severity: Minor
Certolizumab pegol and Influenza virus vaccine quadrivalent recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The recombinant influenza vaccine is non-live, but immunosuppression from certolizumab may reduce the antibody response it generates.
What this interaction means in plain words
Certolizumab pegol and Influenza virus vaccine quadrivalent recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: TNF blockade lowers vaccine immunogenicity.
What to do
Vaccinate as scheduled without interrupting certolizumab. Treat suspected influenza promptly despite vaccination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza virus vaccine quadrivalent recombinant?
MediHelp rates the interaction as minor. Certolizumab pegol and Influenza virus vaccine quadrivalent recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The recombinant influenza vaccine is non-live, but immunosuppression from certolizumab may reduce the antibody response it generates.
How serious is the interaction between Certolizumab pegol and Influenza virus vaccine quadrivalent recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as scheduled without interrupting certolizumab. Treat suspected influenza promptly despite vaccination.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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