Drug interactions
Certolizumab pegol + Influenza virus vaccine quadrivalent
Severity: Minor
Certolizumab pegol and Influenza virus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibody responses to inactivated influenza vaccine may be modestly reduced during TNF inhibitor therapy, but vaccination remains recommended.
What this interaction means in plain words
Certolizumab pegol and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: TNF blockade lowers vaccine-induced immune response.
What to do
Give the inactivated vaccine annually as usual without interrupting certolizumab. Avoid the live intranasal formulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as minor. Certolizumab pegol and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibody responses to inactivated influenza vaccine may be modestly reduced during TNF inhibitor therapy, but vaccination remains recommended.
How serious is the interaction between Certolizumab pegol and Influenza virus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually as usual without interrupting certolizumab. Avoid the live intranasal formulation.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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