Drug interactions
Certolizumab pegol + Influenza virus vaccine trivalent recombinant
Severity: Moderate
Certolizumab pegol and Influenza virus vaccine trivalent recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-TNF therapy can blunt the antibody response to inactivated or recombinant vaccines, so protection from the influenza vaccine may be lower than expected. The vaccine is not live and can be given safely, but its effectiveness may be reduced.
What this interaction means in plain words
Certolizumab pegol and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF blockade dampens immune activation and may reduce vaccine-induced antibody production.
What to do
Give the annual influenza vaccine as recommended despite certolizumab therapy; do not withhold it. Maintain standard infection precautions and consider prompt evaluation of influenza-like illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza virus vaccine trivalent recombinant?
MediHelp rates the interaction as moderate. Certolizumab pegol and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-TNF therapy can blunt the antibody response to inactivated or recombinant vaccines, so protection from the influenza vaccine may be lower than expected. The vaccine is not live and can be given safely, but its effectiveness may be reduced.
How serious is the interaction between Certolizumab pegol and Influenza virus vaccine trivalent recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the annual influenza vaccine as recommended despite certolizumab therapy; do not withhold it. Maintain standard infection precautions and consider prompt evaluation of influenza-like illness.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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