Drug interactions
Certolizumab pegol + Influenza virus vaccine trivalent
Severity: Minor
Certolizumab pegol and Influenza virus vaccine trivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Response to the inactivated trivalent influenza vaccine may be somewhat reduced in patients on TNF inhibitors, though vaccination is still advised.
What this interaction means in plain words
Certolizumab pegol and Influenza virus vaccine trivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism: TNF blockade reduces vaccine-induced antibody production.
What to do
Give the inactivated vaccine yearly without stopping certolizumab. Do not use live attenuated intranasal vaccine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Influenza virus vaccine trivalent?
MediHelp rates the interaction as minor. Certolizumab pegol and Influenza virus vaccine trivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Response to the inactivated trivalent influenza vaccine may be somewhat reduced in patients on TNF inhibitors, though vaccination is still advised.
How serious is the interaction between Certolizumab pegol and Influenza virus vaccine trivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine yearly without stopping certolizumab. Do not use live attenuated intranasal vaccine.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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