Drug interactions
Certolizumab pegol + Meningococcal a c y and w-135 polysaccharide vaccine combined
Severity: Moderate
Certolizumab pegol and Meningococcal a c y and w-135 polysaccharide vaccine combined: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from TNF blockade may weaken the response to meningococcal polysaccharide vaccination. Reduced seroprotection could leave patients vulnerable to invasive meningococcal disease.
What this interaction means in plain words
Certolizumab pegol and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF blockade dampens immune activation and may reduce vaccine-induced antibody production.
What to do
Vaccinate according to national schedules, ideally before starting certolizumab when feasible, and do not delay needed vaccination. Follow booster recommendations for patients on ongoing immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates the interaction as moderate. Certolizumab pegol and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from TNF blockade may weaken the response to meningococcal polysaccharide vaccination. Reduced seroprotection could leave patients vulnerable to invasive meningococcal disease.
How serious is the interaction between Certolizumab pegol and Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to national schedules, ideally before starting certolizumab when feasible, and do not delay needed vaccination. Follow booster recommendations for patients on ongoing immunosuppression.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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