Drug interactions
Certolizumab pegol + Olaparib
Severity: Moderate
Certolizumab pegol and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and certolizumab raises the risk of serious infection. Together, neutropenia could translate into a higher risk of severe infection.
What this interaction means in plain words
Certolizumab pegol and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Olaparib belongs to Oncology.
Why it happens
Additive effects on infection risk: olaparib myelosuppression via PARP inhibition plus TNF-inhibitor immunosuppression.
What to do
Monitor complete blood counts regularly as per olaparib labeling and assess promptly for fever or infection. Interrupt or reduce olaparib for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Certolizumab pegol with Olaparib?
MediHelp rates the interaction as moderate. Certolizumab pegol and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and certolizumab raises the risk of serious infection. Together, neutropenia could translate into a higher risk of severe infection.
How serious is the interaction between Certolizumab pegol and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly as per olaparib labeling and assess promptly for fever or infection. Interrupt or reduce olaparib for significant cytopenias.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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