Drug interactions
Certolizumab pegol + Pegvaliase
Severity: Moderate
Certolizumab pegol and Pegvaliase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvaliase frequently induces anti-PEG antibodies, and certolizumab is a PEGylated Fab fragment. Whether this raises the risk of hypersensitivity or reduced PEGylated drug effect is unknown, though theoretically possible.
What this interaction means in plain words
Certolizumab pegol and Pegvaliase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Pegvaliase belongs to Miscellaneous.
Why it happens
Anti-PEG antibodies induced by pegvaliase may cross-react with the PEG moiety of certolizumab, with possible hypersensitivity or accelerated clearance; not firmly established.
What to do
Monitor for hypersensitivity reactions and loss of certolizumab efficacy after starting pegvaliase. Make sure auto-injectable epinephrine is available per pegvaliase labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Pegvaliase
- Medroxyprogesterone + Pegvaliase Moderate
- Peginterferon alfa 2a + Pegvaliase Moderate
- Peginterferon alfa 2b + Pegvaliase Moderate
Frequently asked questions
Can I take Certolizumab pegol with Pegvaliase?
MediHelp rates the interaction as moderate. Certolizumab pegol and Pegvaliase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvaliase frequently induces anti-PEG antibodies, and certolizumab is a PEGylated Fab fragment. Whether this raises the risk of hypersensitivity or reduced PEGylated drug effect is unknown, though theoretically possible.
How serious is the interaction between Certolizumab pegol and Pegvaliase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypersensitivity reactions and loss of certolizumab efficacy after starting pegvaliase. Make sure auto-injectable epinephrine is available per pegvaliase labeling.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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