Drug interactions
Certolizumab pegol + Pneumococcal vaccine polyvalent
Severity: Moderate
Certolizumab pegol and Pneumococcal vaccine polyvalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitor therapy can lower antibody responses to pneumococcal vaccination, though most patients still achieve some protection. Reduced response matters because these patients have increased infection risk.
What this interaction means in plain words
Certolizumab pegol and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF blockade dampens immune activation and may reduce vaccine-induced antibody production.
What to do
Vaccinate per guidelines, ideally before starting certolizumab, and do not withhold the vaccine. Follow recommended revaccination schedules for immunosuppressed patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Pneumococcal vaccine polyvalent?
MediHelp rates the interaction as moderate. Certolizumab pegol and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. TNF inhibitor therapy can lower antibody responses to pneumococcal vaccination, though most patients still achieve some protection. Reduced response matters because these patients have increased infection risk.
How serious is the interaction between Certolizumab pegol and Pneumococcal vaccine polyvalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate per guidelines, ideally before starting certolizumab, and do not withhold the vaccine. Follow recommended revaccination schedules for immunosuppressed patients.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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