Drug interactions
Certolizumab pegol + Rotavirus oral vaccine live
Severity: Contraindicated
Certolizumab pegol and Rotavirus oral vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral rotavirus vaccine is a live attenuated virus. Infants exposed to certolizumab, such as through breast milk or in utero, or patients treated directly, may be at risk of vaccine-virus infection, though transfer of certolizumab is minimal.
What this interaction means in plain words
Certolizumab pegol and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs immune control of replicating live vaccine virus.
What to do
Avoid rotavirus vaccine in patients receiving certolizumab. For infants of treated mothers, follow current specialist guidance, as certolizumab has minimal placental and milk transfer.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral rotavirus vaccine is a live attenuated virus. Infants exposed to certolizumab, such as through breast milk or in utero, or patients treated directly, may be at risk of vaccine-virus infection, though transfer of certolizumab is minimal.
How serious is the interaction between Certolizumab pegol and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rotavirus vaccine in patients receiving certolizumab. For infants of treated mothers, follow current specialist guidance, as certolizumab has minimal placental and milk transfer.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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