Drug interactions
Certolizumab pegol + Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine
Severity: Minor
Certolizumab pegol and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitor therapy may modestly reduce antibody responses to Tdap, although protective levels are usually still achieved. The vaccine is non-live and should not be withheld.
What this interaction means in plain words
Certolizumab pegol and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF blockade dampens immune activation and may reduce vaccine-induced antibody production.
What to do
Give Tdap on the routine schedule without interrupting certolizumab. Consider additional doses for wound management as per standard guidance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Certolizumab pegol and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as minor. Certolizumab pegol and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. TNF inhibitor therapy may modestly reduce antibody responses to Tdap, although protective levels are usually still achieved. The vaccine is non-live and should not be withheld.
How serious is the interaction between Certolizumab pegol and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give Tdap on the routine schedule without interrupting certolizumab. Consider additional doses for wound management as per standard guidance.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
