Drug interactions
Certolizumab pegol + Typhoid vaccine live
Severity: Contraindicated
Certolizumab pegol and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine contains attenuated Salmonella Typhi. TNF blockade with certolizumab could allow vaccine-strain infection and reduce vaccine response.
What this interaction means in plain words
Certolizumab pegol and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs host defence against replicating live bacteria.
What to do
Use the inactivated Vi polysaccharide typhoid vaccine instead during certolizumab therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live oral typhoid vaccine contains attenuated Salmonella Typhi. TNF blockade with certolizumab could allow vaccine-strain infection and reduce vaccine response.
How serious is the interaction between Certolizumab pegol and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated Vi polysaccharide typhoid vaccine instead during certolizumab therapy.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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