Drug interactions
Certolizumab pegol + Yellow fever vaccine
Severity: Contraindicated
Certolizumab pegol and Yellow fever vaccine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and can cause serious viscerotropic or neurotropic disease in immunosuppressed patients. Certolizumab raises this risk and may weaken protection.
What this interaction means in plain words
Certolizumab pegol and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF blockade impairs antiviral immunity, allowing unchecked replication of the vaccine virus.
What to do
Avoid yellow fever vaccine during certolizumab therapy. If travel to an endemic region cannot be avoided, obtain a medical exemption and advise strict mosquito avoidance.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is live attenuated and can cause serious viscerotropic or neurotropic disease in immunosuppressed patients. Certolizumab raises this risk and may weaken protection.
How serious is the interaction between Certolizumab pegol and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yellow fever vaccine during certolizumab therapy. If travel to an endemic region cannot be avoided, obtain a medical exemption and advise strict mosquito avoidance.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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