Drug interactions
Certolizumab pegol + Zoster vaccine recombinant
Severity: Minor
Certolizumab pegol and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive therapy may reduce the immune response to recombinant zoster vaccine, though it is non-live and is recommended for immunosuppressed adults. Protection may be lower than in untreated people.
What this interaction means in plain words
Certolizumab pegol and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF blockade dampens immune activation and may reduce vaccine-induced antibody production.
What to do
Give the two-dose series per guidelines without stopping certolizumab. Complete the series ideally before intensifying immunosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Certolizumab pegol and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppressive therapy may reduce the immune response to recombinant zoster vaccine, though it is non-live and is recommended for immunosuppressed adults. Protection may be lower than in untreated people.
How serious is the interaction between Certolizumab pegol and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the two-dose series per guidelines without stopping certolizumab. Complete the series ideally before intensifying immunosuppression.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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