Drug interactions
Cevimeline + Cyclosporin
Severity: Minor
Cevimeline and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase cevimeline concentrations, potentially increasing cholinergic effects such as sweating, nausea and diarrhea.
What this interaction means in plain words
Cevimeline and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4-mediated metabolism of cevimeline.
What to do
Monitor for cholinergic adverse effects and reduce the cevimeline dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Cyclosporin?
MediHelp rates the interaction as minor. Cevimeline and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may increase cevimeline concentrations, potentially increasing cholinergic effects such as sweating, nausea and diarrhea.
How serious is the interaction between Cevimeline and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and reduce the cevimeline dose if they become troublesome.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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