Drug interactions
Cevimeline + Diphenoxylate-atropine
Severity: Moderate
Cevimeline and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist, while atropine blocks muscarinic receptors. Atropine may reduce the effect of cevimeline, such as increased salivation, and the drugs oppose each other.
What this interaction means in plain words
Cevimeline and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced cevimeline effect on dry mouth symptoms. Use the antidiarrheal only as needed and consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Cevimeline and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist, while atropine blocks muscarinic receptors. Atropine may reduce the effect of cevimeline, such as increased salivation, and the drugs oppose each other.
How serious is the interaction between Cevimeline and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced cevimeline effect on dry mouth symptoms. Use the antidiarrheal only as needed and consider alternatives.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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