Drug interactions
Cevimeline + Erythromycin
Severity: Moderate
Cevimeline and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is metabolized by CYP3A4 and CYP2D6, and erythromycin can raise its levels. Increased exposure may cause more cholinergic effects such as sweating, nausea, and bradycardia.
What this interaction means in plain words
Cevimeline and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by erythromycin reduces cevimeline clearance.
What to do
Monitor for cholinergic adverse effects and heart rate, especially in patients with cardiac disease or those also taking CYP2D6 inhibitors. Reduce the cevimeline dose if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Erythromycin?
MediHelp rates the interaction as moderate. Cevimeline and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is metabolized by CYP3A4 and CYP2D6, and erythromycin can raise its levels. Increased exposure may cause more cholinergic effects such as sweating, nausea, and bradycardia.
How serious is the interaction between Cevimeline and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and heart rate, especially in patients with cardiac disease or those also taking CYP2D6 inhibitors. Reduce the cevimeline dose if effects occur.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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