Drug interactions
Cevimeline + Fesoterodine
Severity: Moderate
Cevimeline and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist and fesoterodine is an antagonist, so each may blunt the effect of the other. Dry mouth relief from cevimeline may be reduced.
What this interaction means in plain words
Cevimeline and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Fesoterodine belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for loss of cevimeline efficacy and for bladder symptom control, and consider an alternative to fesoterodine if xerostomia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Fesoterodine?
MediHelp rates the interaction as moderate. Cevimeline and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist and fesoterodine is an antagonist, so each may blunt the effect of the other. Dry mouth relief from cevimeline may be reduced.
How serious is the interaction between Cevimeline and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of cevimeline efficacy and for bladder symptom control, and consider an alternative to fesoterodine if xerostomia persists.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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