Drug interactions
Cevimeline + Imipramine
Severity: Moderate
Cevimeline and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist, and imipramine's anticholinergic activity may reduce its effect on salivation. Cevimeline is also metabolized by CYP2D6, which imipramine can inhibit weakly, and cevimeline may affect cardiac conduction.
What this interaction means in plain words
Cevimeline and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at muscarinic receptors, with possible CYP2D6 competition.
What to do
Monitor for diminished saliva-stimulating effect and for cardiovascular effects such as bradycardia or conduction changes. Review the need for the anticholinergic antidepressant if the effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Imipramine?
MediHelp rates the interaction as moderate. Cevimeline and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist, and imipramine's anticholinergic activity may reduce its effect on salivation. Cevimeline is also metabolized by CYP2D6, which imipramine can inhibit weakly, and cevimeline may affect cardiac conduction.
How serious is the interaction between Cevimeline and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished saliva-stimulating effect and for cardiovascular effects such as bradycardia or conduction changes. Review the need for the anticholinergic antidepressant if the effect is lost.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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