Drug interactions
Cevimeline + Nifedipine
Severity: Minor
Cevimeline and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may slightly raise cevimeline levels via CYP3A4 inhibition. Cevimeline cholinergic effects such as sweating or nausea could be modestly intensified. Cevimeline can also have cardiac conduction effects, and calcium channel blockers may add to this concern.
What this interaction means in plain words
Cevimeline and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cevimeline belongs to Miscellaneous; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine reduces cevimeline metabolism.
What to do
Monitor for cholinergic adverse effects and heart rate or conduction disturbances.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Nifedipine?
MediHelp rates the interaction as minor. Cevimeline and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may slightly raise cevimeline levels via CYP3A4 inhibition. Cevimeline cholinergic effects such as sweating or nausea could be modestly intensified. Cevimeline can also have cardiac conduction effects, and calcium channel blockers may add to this concern.
How serious is the interaction between Cevimeline and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and heart rate or conduction disturbances.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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