Drug interactions
Cevimeline + Oxybutynin
Severity: Moderate
Cevimeline and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth, while oxybutynin is an antimuscarinic that commonly causes dry mouth. The two have opposing actions, so cevimeline may be less effective and oxybutynin's bladder effect may also be reduced.
What this interaction means in plain words
Cevimeline and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Oxybutynin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced salivary response to cevimeline and for loss of oxybutynin efficacy; consider an alternative bladder agent with less anticholinergic burden if xerostomia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Oxybutynin?
MediHelp rates the interaction as moderate. Cevimeline and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist used for dry mouth, while oxybutynin is an antimuscarinic that commonly causes dry mouth. The two have opposing actions, so cevimeline may be less effective and oxybutynin's bladder effect may also be reduced.
How serious is the interaction between Cevimeline and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced salivary response to cevimeline and for loss of oxybutynin efficacy; consider an alternative bladder agent with less anticholinergic burden if xerostomia persists.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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