Drug interactions
Cevimeline + Propranolol
Severity: Moderate
Cevimeline and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist with cholinergic effects on the heart, and beta-blockers can add to bradycardia and conduction disturbance. Patients with underlying conduction problems are most at risk. Beta-blockers also may worsen bronchospasm, which is a concern with cevimeline.
What this interaction means in plain words
Cevimeline and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Propranolol belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction (cholinergic stimulation plus beta-blockade) and possible increased airway reactivity.
What to do
Monitor heart rate, ECG if conduction disease is present, and respiratory symptoms. Avoid the combination in patients with significant conduction abnormalities or uncontrolled asthma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Propranolol?
MediHelp rates the interaction as moderate. Cevimeline and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist with cholinergic effects on the heart, and beta-blockers can add to bradycardia and conduction disturbance. Patients with underlying conduction problems are most at risk. Beta-blockers also may worsen bronchospasm, which is a concern with cevimeline.
How serious is the interaction between Cevimeline and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG if conduction disease is present, and respiratory symptoms. Avoid the combination in patients with significant conduction abnormalities or uncontrolled asthma.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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