Drug interactions
Cevimeline + Timolol
Severity: Moderate
Cevimeline and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances, and patients taking beta-blockers may be at greater risk of conduction abnormalities. The combination is described in labeling as a caution.
What this interaction means in plain words
Cevimeline and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Timolol belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction from beta-blockade and muscarinic stimulation.
What to do
Monitor heart rate and ECG in patients with cardiac disease when the two are combined. Avoid cevimeline in patients with uncontrolled asthma or significant conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Timolol?
MediHelp rates the interaction as moderate. Cevimeline and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist that can cause bradycardia and conduction disturbances, and patients taking beta-blockers may be at greater risk of conduction abnormalities. The combination is described in labeling as a caution.
How serious is the interaction between Cevimeline and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease when the two are combined. Avoid cevimeline in patients with uncontrolled asthma or significant conduction disease.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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