Drug interactions
Cevimeline + Tolterodine
Severity: Moderate
Cevimeline and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth, and tolterodine is a muscarinic antagonist. Tolterodine can blunt the salivary effect of cevimeline and cevimeline may reduce the bladder effect of tolterodine.
What this interaction means in plain words
Cevimeline and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Opposing pharmacodynamic effects at muscarinic receptors.
What to do
Monitor for loss of efficacy of either drug. Consider an alternative to tolterodine if dry mouth symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cevimeline and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolterodine
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Tolterodine?
MediHelp rates the interaction as moderate. Cevimeline and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist used for dry mouth, and tolterodine is a muscarinic antagonist. Tolterodine can blunt the salivary effect of cevimeline and cevimeline may reduce the bladder effect of tolterodine.
How serious is the interaction between Cevimeline and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy of either drug. Consider an alternative to tolterodine if dry mouth symptoms are not controlled.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
