Drug interactions
Chloral hydrate + Dobutamine
Severity: Moderate
Chloral hydrate and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate has been associated with arrhythmias, and its metabolite sensitizes the myocardium to catecholamines. Combined with dobutamine, ventricular arrhythmias may be more likely.
What this interaction means in plain words
Chloral hydrate and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Dobutamine belongs to Cardiovascular.
Why it happens
Myocardial sensitization to catecholamines by chloral hydrate metabolites.
What to do
Monitor ECG continuously and consider an alternative sedative if arrhythmias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Dobutamine?
MediHelp rates the interaction as moderate. Chloral hydrate and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate has been associated with arrhythmias, and its metabolite sensitizes the myocardium to catecholamines. Combined with dobutamine, ventricular arrhythmias may be more likely.
How serious is the interaction between Chloral hydrate and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG continuously and consider an alternative sedative if arrhythmias occur.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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