Drug interactions
Chloral hydrate + Lofexidine
Severity: Moderate
Chloral hydrate and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a centrally acting alpha-2 agonist that causes sedation and hypotension, which can add to the effects of chloral hydrate. The combination may cause excessive drowsiness, low blood pressure and bradycardia.
What this interaction means in plain words
Chloral hydrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from alpha-2 agonism plus a sedative-hypnotic.
What to do
Monitor sedation, blood pressure and pulse, and reduce doses if needed. Advise patients to rise slowly and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Chloral hydrate with Lofexidine?
MediHelp rates the interaction as moderate. Chloral hydrate and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a centrally acting alpha-2 agonist that causes sedation and hypotension, which can add to the effects of chloral hydrate. The combination may cause excessive drowsiness, low blood pressure and bradycardia.
How serious is the interaction between Chloral hydrate and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and pulse, and reduce doses if needed. Advise patients to rise slowly and avoid driving.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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