Drug interactions
Chlorambucil + Cyclophosphamide
Severity: Moderate
Chlorambucil and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are alkylating agents with bone marrow toxicity, so combined use increases the likelihood and depth of cytopenias and infection.
What this interaction means in plain words
Chlorambucil and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Cyclophosphamide belongs to Oncology.
Why it happens
Additive myelosuppression from two DNA-alkylating agents.
What to do
Monitor complete blood counts frequently and reduce doses or delay therapy if counts fall significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Chlorambucil
Frequently asked questions
Can I take Chlorambucil with Cyclophosphamide?
MediHelp rates the interaction as moderate. Chlorambucil and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are alkylating agents with bone marrow toxicity, so combined use increases the likelihood and depth of cytopenias and infection.
How serious is the interaction between Chlorambucil and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay therapy if counts fall significantly.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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