Drug interactions
Chloramphenicol + Cholera vaccine
Severity: Moderate
Chloramphenicol and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral cholera vaccine contains live attenuated bacteria that need to replicate in the gut. Systemic antibiotics such as chloramphenicol may kill the vaccine strain and reduce the immune response.
What this interaction means in plain words
Chloramphenicol and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces colonization and immunogenicity.
What to do
Avoid giving the vaccine to patients who have taken systemic antibiotics within the 14 days before vaccination, as per labeling. Delay vaccination until the antibiotic course is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Cholera vaccine?
MediHelp rates the interaction as moderate. Chloramphenicol and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral cholera vaccine contains live attenuated bacteria that need to replicate in the gut. Systemic antibiotics such as chloramphenicol may kill the vaccine strain and reduce the immune response.
How serious is the interaction between Chloramphenicol and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the vaccine to patients who have taken systemic antibiotics within the 14 days before vaccination, as per labeling. Delay vaccination until the antibiotic course is complete.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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