Drug interactions
Chloramphenicol + Copanlisib
Severity: Moderate
Chloramphenicol and Copanlisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Copanlisib is mainly metabolized by CYP3A4, so chloramphenicol may increase its exposure and the risk of hyperglycemia, hypertension, infections and neutropenia.
What this interaction means in plain words
Chloramphenicol and Copanlisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of copanlisib.
What to do
Use an alternative antibiotic if possible. If combined, monitor blood glucose, blood pressure and blood counts, and consider reducing the copanlisib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Copanlisib?
MediHelp rates the interaction as moderate. Chloramphenicol and Copanlisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Copanlisib is mainly metabolized by CYP3A4, so chloramphenicol may increase its exposure and the risk of hyperglycemia, hypertension, infections and neutropenia.
How serious is the interaction between Chloramphenicol and Copanlisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If combined, monitor blood glucose, blood pressure and blood counts, and consider reducing the copanlisib dose.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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