Drug interactions
Chloramphenicol + Diazepam intranasal
Severity: Moderate
Chloramphenicol and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic enzymes and may slow the clearance of diazepam, prolonging and intensifying its sedative and respiratory depressant effects. The effect is more important in older patients or those with liver impairment.
What this interaction means in plain words
Chloramphenicol and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C19 and CYP3A4-mediated diazepam metabolism.
What to do
Monitor for excessive sedation and respiratory depression, and consider reducing the diazepam dose or avoiding repeat dosing within a short interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Diazepam intranasal?
MediHelp rates the interaction as moderate. Chloramphenicol and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic enzymes and may slow the clearance of diazepam, prolonging and intensifying its sedative and respiratory depressant effects. The effect is more important in older patients or those with liver impairment.
How serious is the interaction between Chloramphenicol and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and consider reducing the diazepam dose or avoiding repeat dosing within a short interval.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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