Drug interactions
Chloramphenicol + Elbasvir / grazoprevir
Severity: Major
Chloramphenicol and Elbasvir / grazoprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase grazoprevir and elbasvir exposure. Raised grazoprevir levels are linked to a higher risk of ALT elevations and hepatotoxicity.
What this interaction means in plain words
Chloramphenicol and Elbasvir / grazoprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by chloramphenicol reduces the metabolism of elbasvir and grazoprevir.
What to do
Avoid the combination and use a non-interacting antibiotic. If coadministration cannot be avoided, monitor liver enzymes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Elbasvir / grazoprevir?
MediHelp rates the interaction as major. Chloramphenicol and Elbasvir / grazoprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may inhibit CYP3A4 and increase grazoprevir and elbasvir exposure. Raised grazoprevir levels are linked to a higher risk of ALT elevations and hepatotoxicity.
How serious is the interaction between Chloramphenicol and Elbasvir / grazoprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-interacting antibiotic. If coadministration cannot be avoided, monitor liver enzymes closely.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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