Drug interactions
Chloramphenicol + Fluticasone inhaled
Severity: Moderate
Chloramphenicol and Fluticasone inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluticasone is cleared extensively by CYP3A4, and strong inhibitors such as ritonavir have caused systemic corticosteroid effects. Chloramphenicol could in theory raise systemic fluticasone levels, leading to adrenal suppression and Cushingoid features with prolonged use.
What this interaction means in plain words
Chloramphenicol and Fluticasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4, which may reduce first-pass and systemic clearance of fluticasone.
What to do
Monitor for signs of systemic corticosteroid excess during prolonged coadministration. Consider an alternative steroid such as beclomethasone if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Fluticasone inhaled?
MediHelp rates the interaction as moderate. Chloramphenicol and Fluticasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluticasone is cleared extensively by CYP3A4, and strong inhibitors such as ritonavir have caused systemic corticosteroid effects. Chloramphenicol could in theory raise systemic fluticasone levels, leading to adrenal suppression and Cushingoid features with prolonged use.
How serious is the interaction between Chloramphenicol and Fluticasone inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during prolonged coadministration. Consider an alternative steroid such as beclomethasone if long-term use is needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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