Drug interactions
Chloramphenicol + Glibenclamide
Severity: Moderate
Chloramphenicol and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can decrease the metabolism of glyburide, increasing drug levels and the risk of prolonged or severe hypoglycemia. Patients with reduced renal function or erratic intake are at greater risk.
What this interaction means in plain words
Chloramphenicol and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Glibenclamide belongs to Endocrine.
Why it happens
Chloramphenicol inhibits hepatic CYP enzymes (notably CYP2C9) responsible for glyburide clearance.
What to do
Check blood glucose frequently while both drugs are used and when chloramphenicol is stopped. Reduce the glyburide dose or switch agents if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloramphenicol and Glibenclamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloramphenicol
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Chloramphenicol with Glibenclamide?
MediHelp rates the interaction as moderate. Chloramphenicol and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can decrease the metabolism of glyburide, increasing drug levels and the risk of prolonged or severe hypoglycemia. Patients with reduced renal function or erratic intake are at greater risk.
How serious is the interaction between Chloramphenicol and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently while both drugs are used and when chloramphenicol is stopped. Reduce the glyburide dose or switch agents if hypoglycemia occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
