Drug interactions
Chloramphenicol + Glimepiride-pioglitazone
Severity: Moderate
Chloramphenicol and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic drug metabolism and can raise sulfonylurea levels, increasing the risk of hypoglycemia with glimepiride. Pioglitazone exposure may also rise.
What this interaction means in plain words
Chloramphenicol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 and other hepatic enzymes reduces metabolism of glimepiride.
What to do
Monitor blood glucose closely during chloramphenicol therapy and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Chloramphenicol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic drug metabolism and can raise sulfonylurea levels, increasing the risk of hypoglycemia with glimepiride. Pioglitazone exposure may also rise.
How serious is the interaction between Chloramphenicol and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during chloramphenicol therapy and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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