Drug interactions
Chloramphenicol + Infigratinib
Severity: Major
Chloramphenicol and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized primarily by CYP3A4, so inhibition may raise its concentrations. This could increase hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Chloramphenicol and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing infigratinib clearance.
What to do
Use an alternative antibiotic where feasible. If coadministered, monitor serum phosphate and ocular symptoms and reduce the infigratinib dose if toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Infigratinib?
MediHelp rates the interaction as major. Chloramphenicol and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib is metabolized primarily by CYP3A4, so inhibition may raise its concentrations. This could increase hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Chloramphenicol and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where feasible. If coadministered, monitor serum phosphate and ocular symptoms and reduce the infigratinib dose if toxicity occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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