Drug interactions
Chloramphenicol + Lumefantrine
Severity: Moderate
Chloramphenicol and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4 and can prolong the QT interval at higher exposures. Chloramphenicol may raise lumefantrine levels and potentially increase this risk.
What this interaction means in plain words
Chloramphenicol and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated lumefantrine metabolism.
What to do
Monitor ECG when other QT risk factors exist and correct electrolytes. Consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Lumefantrine?
MediHelp rates the interaction as moderate. Chloramphenicol and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is metabolized by CYP3A4 and can prolong the QT interval at higher exposures. Chloramphenicol may raise lumefantrine levels and potentially increase this risk.
How serious is the interaction between Chloramphenicol and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when other QT risk factors exist and correct electrolytes. Consider an alternative antibiotic.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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