Drug interactions
Chloramphenicol + Midazolam intranasal
Severity: Moderate
Chloramphenicol and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4 and raise midazolam exposure. This may deepen and prolong sedation and increase the risk of respiratory depression.
What this interaction means in plain words
Chloramphenicol and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4-mediated metabolism of midazolam, reducing its clearance.
What to do
Monitor sedation level and respiratory status closely after intranasal midazolam and allow longer observation before discharge or redosing. Avoid repeat dosing earlier than usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Midazolam intranasal?
MediHelp rates the interaction as moderate. Chloramphenicol and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit CYP3A4 and raise midazolam exposure. This may deepen and prolong sedation and increase the risk of respiratory depression.
How serious is the interaction between Chloramphenicol and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status closely after intranasal midazolam and allow longer observation before discharge or redosing. Avoid repeat dosing earlier than usual.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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