Drug interactions
Chloramphenicol + Olaparib
Severity: Major
Chloramphenicol and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized by CYP3A4, and inhibitors raise its exposure. This may increase myelosuppression such as anemia and neutropenia.
What this interaction means in plain words
Chloramphenicol and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Olaparib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing olaparib clearance.
What to do
Avoid if possible. If unavoidable, reduce the olaparib dose per labeling for strong CYP3A inhibitors and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Chloramphenicol with Olaparib?
MediHelp rates the interaction as major. Chloramphenicol and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib is metabolized by CYP3A4, and inhibitors raise its exposure. This may increase myelosuppression such as anemia and neutropenia.
How serious is the interaction between Chloramphenicol and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the olaparib dose per labeling for strong CYP3A inhibitors and monitor blood counts.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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