Drug interactions
Chloramphenicol + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Chloramphenicol and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir and ritonavir in this regimen are CYP3A4 substrates, so chloramphenicol may increase their exposure. This may raise the risk of hepatic and other adverse effects.
What this interaction means in plain words
Chloramphenicol and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing clearance of paritaprevir and ritonavir.
What to do
Use an alternative antibiotic when possible. If co-administered, monitor liver tests and clinical tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Chloramphenicol and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paritaprevir and ritonavir in this regimen are CYP3A4 substrates, so chloramphenicol may increase their exposure. This may raise the risk of hepatic and other adverse effects.
How serious is the interaction between Chloramphenicol and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when possible. If co-administered, monitor liver tests and clinical tolerability.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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