Drug interactions
Chloramphenicol + Ombitasvir / paritaprevir / ritonavir
Severity: Moderate
Chloramphenicol and Ombitasvir / paritaprevir / ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir and ritonavir are CYP3A4 substrates, and chloramphenicol may raise their concentrations. This could increase hepatic and other adverse effects of the regimen.
What this interaction means in plain words
Chloramphenicol and Ombitasvir / paritaprevir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4, which reduces metabolism of paritaprevir and ritonavir.
What to do
Choose a non-interacting antibiotic where feasible. If the combination is used, monitor liver function and for adverse effects of the antiviral regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Ombitasvir / paritaprevir / ritonavir?
MediHelp rates the interaction as moderate. Chloramphenicol and Ombitasvir / paritaprevir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paritaprevir and ritonavir are CYP3A4 substrates, and chloramphenicol may raise their concentrations. This could increase hepatic and other adverse effects of the regimen.
How serious is the interaction between Chloramphenicol and Ombitasvir / paritaprevir / ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-interacting antibiotic where feasible. If the combination is used, monitor liver function and for adverse effects of the antiviral regimen.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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